Check it out: Researchers Discover New Therapeutic Target To Combat Liver Cancer

Using computer models and laboratory experiments, scientists have probed the structure of the protein mitoNEET to better understand its role in aging, cancer and diabetes. They found the protein could untangle its arms at one end to loosen its grip on a potentially toxic molecule of iron and sulfur. ... more

Data could lead to better advice for primary-care doctors struggling with a rising tide of older adult patients still in throes of youthful bad habits. ... more

Life-changing diagnosis of cancer can inspire you to pass down a legacy to future generations. ... more

I love listening to life stories.  As a hospice chaplain, I loved sitting with our patients and their loved ones engaging in what many hospice teams call ��life review. ��  When did you meet your spouse?  When was Reggie born?  What is your favorite holiday?  When did you learn you were ill?  A few simple questions and the stories come pouring forth.Of late, I ��ve been listening to the life stories of Gen X individuals whose Baby Boomer mom or dad, stepmom or stepdad, died in the fall of ... more

On Friday, the US Food and Drug Administration finally approved Amylin Pharmaceutical's diabetes drug Bydureon, which provides glycemic control for diabetes type 2 in a once-weekly injection. The approval follows two earlier rejections in 2010, when the FDA asked the company to go back and carry out a new trial of the drug's effect on heart rhythm. The company describes Bydureon (exenatide extended-release for injectable suspension) as the first of its kind. It is a once-a- week version of ... more

A two-year study of nearly 190,000 girls and women, finds that Gardasil, the human papillomavirus (HPV) vaccine made by Merck Co, does not trigger autoimmune disorders such as lupus, rheumatoid arthritis, type 1 diabetes and multiple sclerosis. The results are published in the Journal of Internal Medicine. Study lead author Dr Chun Chao, a research scientist at the Kaiser Permanente Department of Research Evaluation in Pasadena, California, said in a statement released on Friday, that: " ... more

about 80 y old patient with congestive heart failure and sepsis with pulmonary focus (gram-stain: gram-positive cluster coccal). In TEE we found a floating structure an posterior leaf of mital valve. not typical for active endocarditis. What could it be? We thought it could be a residual of a former endocarditis or a calcified residual of tendon of papillary muscle. What do you think? Added by: Emmel Tags: TEE ICU posterior mitral leaf Date: 2012-01-28 ... more

On Friday, the US Food and Drug Administration finally approved Amylin Pharmaceutical's diabetes drug Bydureon, which provides glycemic control for diabetes type 2 in a once-weekly injection. The approval follows two earlier rejections in 2010, when the FDA asked the company to go back and carry out a new trial of the drug's effect on heart rhythm... ... more

Survivors of Hurricane Katrina have struggled with poor mental health for years after the storm, according to a new study of low-income mothers in the New Orleans area. ... more

Asian women who consumed an average of 200 milligrams or more of caffeine a day -- the equivalent of roughly two cups of coffee -- had elevated estrogen levels when compared to women who consumed less, according to a study of reproductive age women. ... more

Researchers have found a new gene that, when mutated, can lead to lymphedema (swollen limbs) as part of a rare disorder that can also cause problems with eye and brain development. This is the fourth lymphedema-related gene found by the same researchers in three years, and the first linked to the eyes and brain. They say it could lead to better diagnosis and treatment for lymphedema, an area that has been poorly understood previously. ... more

New anti-cancer research has led to the development of a novel class of chemical inhibitors that specifically target cancer cells with pluripotency. ... more

Good news for the 13 per cent of the population with depressive personality traits: their negative outlook does not have to be permanent, according to new research from Sweden. ... more

For type 2 diabetics who are not on insulin, monitoring their blood sugar does little to control blood sugar levels over time and may not be worth the effort or expense, according to a new evidence review. ... more

How many times as a doctor do you ask the same questions over and over again as part of the routine process of taking a history from your patient?  And how often as a patient do you have to answer those same questions each time you see a new doctor? How long does this take, given that doctors and patients both complain that there is too little time for the modern consultation to cover all the bases to the satisfaction of both parties?Read the rest of Repetition is the curse of the doctor-patien ... more

Do you get a headache from the perfume of the lady next to you at the table? Do cleaning solutions at work make your nose itch? If you have symptoms prompted by everyday smells, it does not necessaril ... more

FoodSwitch, an Australian-first iPhone app, has been launched recently to help shoppers make healthier food choices in the supermarket and reduce high levels of fat, salt and sugar from their diets. ... more

The use of statins in postmenopausal women is associated with increased diabetes risk, according to a study published Online First by the Archives of Internal Medicine, one of the JAMA/Archives journa ... more

Ads by GoogleLatest Energy ResearchRenewable energy and climate change report from the IPCC. www.cambridge.org/renewable A generic photo of prescription drugs taken March 20, 2009 for files. (PAUL J. RICHARDS/AFP/Getty Images) A father who has lost two sons to war told The Daily Caller that the U.S. Central Command ��s policy of allowing troops to deploy with a 180-day supply of the antip ... more

via theatlantic.com Posted via email from Jack's posterous ... more

Ads by GoogleLatest Energy ResearchRenewable energy and climate change report from the IPCC. www.cambridge.org/renewable A generic photo of prescription drugs taken March 20, 2009 for files. (PAUL J. RICHARDS/AFP/Getty Images) A father who has lost two sons to war told The Daily Caller that the U.S. Central Command ��s policy of allowing troops to deploy with a 180-day supply of the antip ... more

via theatlantic.com Posted via email from Jack's posterous ... more

Teaching children with autism to "talk things through" in their heads may help them solve tricky day-to-day tasks and could increase the chances of them living independent lives when they grow up. Reuters Health Information ... more

Gang-related deaths typically aren't the product of fights over drugs -- as many assume -- but rather result from grudges between rival gangs that erupt into violence. Reuters Health Information ... more

Source: American Psychiatric Association - - PDF Related MedlinePlus Page: Autism ... more

Source: American Psychological Association Related MedlinePlus Page: Teen Mental Health ... more

Test your medicine knowledge with the MKSAP challenge, in partnership with the American College of Physicians.A 58-year-old woman is hospitalized for acute left-sided flank pain. She has had fever and night sweats for 1 month and a 9.1-kg (20-lb) weight loss over 6 months.On physical examination, temperature is 37.7 °C (99.8 °F), blood pressure is 135/88 mm Hg, pulse is 88/min, and respiration rate is 18/min. Heart sounds are normal. There is an early diastolic low-pitched sound after the S2 ... more

It was 1976 and I was a junior resident in urology at Baylor College of Medicine in Houston, Texas.  I was assigned to a rotation in pathology where my job was to process specimens taken at surgery, dictate a gross description of the specimen and then place the specimens into the cassettes that would be used to make the permanent sections.  I was transferring a prostate biopsy, approximately 0.5mm x 10mm, and it slipped from the forceps and was washed down the drain of the sink.  I searched f ... more

Adding lights, exercise can help people battling seasonal affective disorder, doctor says ... more

Players should take their time, but not too long, study contends ... more

Researchers at the National Institute of Health, along with other institutions, have released a study online in the American Journal of Clinical Nutrition, stating that Asian women have higher estrogen levels when drinking 200 milligrams or more of caffeine a day. This is about 2 cups of coffee. On the other hand, white women who drank the same amount tended to have lower estrogen levels than those who did not drink this amount of caffeine... ... more

Despite a decrease in home births between 1990 and 2004, the number of home births actually increased between 2004 and 2009 by 29%, an upturn of 0.56% in 2004, to 0.72% in 2009. In 2009, a total of 29,650 home births were reported in the United States. This is the most home births reported since researchers began analyzing data on this topic in 1989. The report, called "Home Births in the United States, 1990-2009", was issued by the National Center for Health Statistics, part of the CDC (Centers ... more

Scientists have connected two signature characteristics of pancreatic cancer, identifying a self-perpetuating "vicious cycle" of molecular activity and a new potential target for drugs to treat one of the most lethal forms of cancer. The research, reported in the journal Cancer Cell and led by scientists at The University of Texas MD Anderson Cancer Center, connected the molecular dots between: Mutated versions of Kras, a gene that acts as a molecular on-off switch but gets stuck in the "on ... more

A hallmark of the individual is the cultivation of personal interests, but for some people, their intellectual pursuits might actually be genetically predetermined. Survey results published by Princeton University researchers in the journal PLoS ONE suggest that a family history of psychiatric conditions such as autism and depression could influence the subjects a person finds engaging. Although preliminary, the findings provide a new look at the oft-studied link between psychiatric conditions a ... more

Rheumatoid arthritis (RA) is a chronic inflammatory disease where the body begins to attack the joints and organs of the body. Proteins within inflamed joints are often modified by citrullination, a process that converts the protein building block arginine into citrulline. These two amino acids have very different physical properties and consequently conversion can result in aberrant changes in the three-dimensional structure of an affected protein... ... more

All living organisms are made up of cells, behind these intricate life forms lie complex cellular processes that allow our bodies to function. Researchers working on protein secretion - a fundamental process in biology - have revealed how protein channels in the membrane are activated by special signals contained in proteins destined for secretion. The results help explain the underlying mechanism responsible for the release of proteins such as hormones and antibodies into the blood stream... ... more

Researchers at CIC Biogune, the Cooperative Centre for Research into Biosciences and led by Dr. Maria Luz Martinez Chantar, have found a strong relationship between high levels of Hu antigen R (HuR) protein and the malignancy of Hepatocellular Carcinoma, through a novel molecular process in the investigation of this pathology and known as neddylation. The project provides new opportunities for making advances in the quest for personalised therapeutic applications in the treatment for Hepatocarci ... more

Women who consumed a diet high in animal fat and cholesterol before pregnancy were at higher risk for gestational diabetes than women whose diets were lower in animal fat and cholesterol, according to researchers at the National Institutes of Health and Harvard University. Gestational diabetes is a form of diabetes seen during pregnancy. Gestational diabetes increases the risk for certain pregnancy complications and health problems in the newborn. Women whose diets were high in total fat or othe ... more

Brachytherapy for high-risk prostate cancers patients has historically been considered a less effective modality, but a new study from radiation oncologists at the Kimmel Cancer Center at Jefferson suggests otherwise. A population-based analysis looking at almost 13,000 cases revealed that men who received brachytherapy alone or in combination with external beam radiation therapy (EBRT) had significantly reduced mortality rates. Their findings are reported online in the International Journal of ... more

Rapid discontinuation of the immunosuppressive steroid prednisone after a kidney transplant can help prevent serious side effects, according to a study appearing in an upcoming issue of the Clinical Journal of the American Society Nephrology (CJASN). Also, doing so does not appear to jeopardize the long-term survival of transplant patients and their new organs. Historically, most kidney transplant patients have taken large doses of the immunosuppressive steroid prednisone to help keep their bodi ... more

A new study uses a mouse model of a human autoimmune disease to reveal how abnormal regulation of the intracellular sensors that detect invading viruses can lead to autoimmune pathology. The research, published online in the journal Immunity by Cell Press, provides key insight into mechanisms that underlie the development of autoimmune disease and may lead to more effective strategies for therapeutic intervention. There are multiple intracellular sensors that detect viral infection by binding to ... more

A new study unravels key signals that regulate protective and sometimes pathological inflammation of the skin. The research, published online in the journal Immunity by Cell Press, identifies a "gatekeeper" that, when lost, can cause inflammatory skin disease in the absence of injury or infection. The findings may eventually lead to new treatment strategies for the more than 10% of people in the western world that suffer from inflammatory skin diseases... ... more

A team led by researchers at the University of California, San Diego School of Medicine reports that newly discovered mutations in an evolved assembly of genes cause Joubert syndrome, a form of syndromic autism. The findings are published in the online issue of Science Express. Joubert syndrome is a rare, recessive brain condition characterized by malformation or underdevelopment of the cerebellum and brainstem. The disease is due specifically to alterations in cellular primary cilia - antenna-l ... more

Your genes could be a strong predictor of whether you stray into a life of crime, according to a research paper co-written by UT Dallas criminologist Dr. J.C. Barnes. "Examining the Genetic Underpinnings to Moffitt's Developmental Taxonomy: A Behavior Genetic Analysis" detailed the study's findings in a recent issue of Criminology. The paper was written with Dr. Kevin M. Beaver from Florida State University and Dr. Brian B. Boutwell at Sam Houston State University... ... more

The percentage of people screened for cancer in the US remains below national targets for 2020, with rates lower among Asian and Hispanic Americans than other groups, according to a new report by the Centers for Disease Control and Prevention (CDC) and the National Cancer Institute (NCI) released on Friday. The report shows that in 2010, the screening rate for breast cancer was 72.4%, compared to the 2020 national target of 81%, for cervical cancer it was 83%, compared to a target of 93%, a ... more

This week ��s Wall Street Journal has two physicians debating whether the doctor-patient relationship should be extended to email. While both of these doctors agree that email correspondence can ��t substitute for an office exam, questions remain about whether this new channel of communication will create or quell confusion. ... more

Oropharyngeal cancer, which affects the throat, tongue, soft palate, and tonsils, has become increasingly common among men in the U.S. Because a distinct form of it is caused primarily by HPV (human papillomavirus), a recent study set out to determine the prevalence of oral HPV infection. attack. ... more

Diabetes, hypertension, high cholesterol, smoking. These have long been recognized as major risk factors for cardiovascular disease. Now, a study just published in the New England Journal of Medicine starkly demonstrates just how significantly these factors increase a person ��s risk of stroke or heart attack. ... more

TTE parasternal long axis,mmode recording and apical views ,show pericardial tumor(extension from mediastinal lymphoma),compressing the LV. Added by: magehana47 Tags: tumor pericardial mediastinal Date: 2012-01-28 ... more

pericardial and pleural extension from lung sarcoma. Added by: magehana47 Tags: tumor sarcoma pericardial Date: 2012-01-28 ... more

Women who consumed a diet high in animal fat and cholesterol before pregnancy were at higher risk for gestational diabetes than women whose diets were lower in animal fat and cholesterol, according to researchers at the National Institutes of Health and Harvard University. Gestational diabetes is a form of diabetes seen during pregnancy... ... more

Researchers at CIC Biogune, the Cooperative Centre for Research into Biosciences and led by Dr. Maria Luz Martinez Chantar, have found a strong relationship between high levels of Hu antigen R (HuR) protein and the malignancy of Hepatocellular Carcinoma, through a novel molecular process in the investigation of this pathology and known as neddylation... ... more

The percentage of people screened for cancer in the US remains below national targets for 2020, with rates lower among Asian and Hispanic Americans than other groups, according to a new report by the Centers for Disease Control and Prevention (CDC) and the National Cancer Institute (NCI) released on Friday. The report shows that in 2010, the screening rate for breast cancer was 72... ... more

The FDA has given its nod to Bydureon, making it the first weekly treatment for type 2 diabetes, according to drug's manufacturer. ... more

Measuring brain activity in infants as young as six months may help to predict the future development of autism symptoms. In their first year of life, babies who will go on to develop autism already show different brain responses when someone looks at or away from them. The findings suggest that direct brain measures might help to predict the future development of autism symptoms in infants as young as six months. ... more

When people in the U.S. are asked to provide their weight for research surveys, they underestimate their weight and overestimate their height, despite numerous public reports about increasing rates of obesity. Whites are more likely to do so than Blacks or Hispanics, finds a new study. ... more

How will you feel if you fail that test? Awful, really awful, you say. Then you fail the test and, yes, you feel bad -- but not as bad as you thought you would. This pattern holds for most people, research shows. The takeaway message: People are lousy at predicting their emotions. ... more

Researchers have discovered that a molecule critical to the development and plasticity of nerve cells �� brain-derived neurotrophic factor -- is severely lacking in brainstem neurons in mutations leading to Rett syndrome, a neurological developmental disorder. The finding has implications for the treatment of neurological disorders, including Rett syndrome that affects one in 10,000 baby girls. ... more

Analysts expect annual sales of Bydureon to eventually exceed $1 billion. But they are less enthusiastic than they once were, in part because of safety concerns involving thyroid cancer and pancreatitis. David Kliff, publisher of Diabetic Investor, an electronic newsletter following the diabetes industry, said a once-weekly self-injection could make Bydureon an alternative for many patients to multiple insulin injections or even to multiple pills every day. via nytimes.com P ... more

Analysts expect annual sales of Bydureon to eventually exceed $1 billion. But they are less enthusiastic than they once were, in part because of safety concerns involving thyroid cancer and pancreatitis. David Kliff, publisher of Diabetic Investor, an electronic newsletter following the diabetes industry, said a once-weekly self-injection could make Bydureon an alternative for many patients to multiple insulin injections or even to multiple pills every day. via nytimes.com P ... more

Children who develop autism already show signs of different brain responses in their first year of life. Reuters Health Information ... more

Jean-Claude Mas, the Frenchman who has sparked a global health scare by selling substandard breast implants, was arrested on Thursday. Reuters Health Information ... more

Long-term follow-up of high-risk patients with squamous cell carcinoma shows that some subgroups benefit from postoperative concurrent chemoradiation therapy and others don't. Medscape Medical News ... more

NIDA has released a new tool that aims to help clinicians and patients better evaluate addiction treatment programs. Medscape Medical News ... more

Despite the mixed data from the clinical trials, experts say there are some parenting strategies, such as monitoring unhealthy behaviors and positive reinforcement, that are helpful in getting children to change their behavior and lose weight. Heartwire ... more

The Centers for Medicare and Medicaid Services' Medicare Evidence Development and Coverage Advisory Committee met to once again discuss the latest available evidence on different treatments of carotid atherosclerosis, and the only clear message was these questions remain a moving target. Heartwire ... more

More than 100 people have died in Pakistan and hundreds more have been hospitalized after having received contaminated cardiac drugs. Heartwire ... more

Proximal balloon-occlusion devices do not cross the lesion before it is stented, which helps to significantly reduce embolic load in the brain during the carotid procedure, according to researchers. Heartwire ... more

It may have little to offer and it might not be what the patient wants, argues a perspective in the New England Journal of Medicine. Heartwire ... more

In a large population of young women aged 9 to 26 years receiving quadrivalent human papillomavirus vaccine, researchers found no increase in new-onset cases for 16 autoimmune conditions surveyed. Medscape Medical News ... more

An EMAS position statement on the role of vitamin D after menopause notes that the recommended daily allowance is 600 IU/day, or 800 IU/day for those 71 years and older. Medscape Medical News ... more

Joint surgery rates have declined since 1980 among patients with rheumatoid arthritis, suggesting that treatment is changing the course of disease. Medscape Medical News ... more

The FDA approved the once-weekly version of exenatide for type 2 diabetes with a list of required postmarketing studies on the potential for cardiovascular events and medullary thyroid carcinoma. FDA Approvals ... more

Diagnosis is the foundation on which all care and treatments rest.  If the diagnosis is wrong, most probably so is the treatment.  Diagnosing an illness is an art.  A diagnostician needs to be one part scholar, one part detective, and four parts artist.  He has to be a good listener, open minded, and capable of assimilating a large amount of sometimes confusing data into an accurate picture of a disease process.  A diagnostician must also be humble, capable of seeking help and counsel from ... more

Unfair treatment that is race-based linked to reports of poor health in both blacks and whites ... more

Tips on helping overweight children get to a healthy weight, no matter how old they are ... more

A new study offers a scientific explanation for why walking in high heels can be so painful: It changes the basic mechanics of how women walk. ... more

WebMD talks to experts about the possible health benefits of marriage and other long-term relationships ... more

Researchers report that low-dose Campath (alemtuzumab) not only treats patients with L-CTCL but does so without increasing their risk of infections. ... more

For years it was thought that a difficult birth and other perinatal factors were the leading causes of cerebral palsy (CP), a group of disorders that can involve brain and nervous system functions such as movement, learning, hearing, seeing and thinking. Now, researchers suggest that the majority of cerebral palsy causes may in fact be caused by genetic abnormalities. ... more

Could depression in adulthood be tied to a parent's level of education? A new study by a medical sociologist suggests this is the case. ... more

Researchers have developed what they believe to be the first clinical application of a new imaging technique to diagnose brain tumors. ... more

Study in model that mimics human effects of multiparity (giving birth more than once) finds mouse moms who gave birth 4 times accrued significantly more fat vs. primiparous females (those giving birth once) of similar age. Multiparous moms also had more liver inflammation. ... more

Researchers have discovered that the most common receptor for the major neurotransmitter in the brain is also present in the eye, which may explain links between cataracts, epilepsy and use of a number of antiepileptic and antidepressant drugs. ... more

Scientists have discovered key elements of a strategy commonly used by tumor cells to survive when they spread to distant organs. The finding could lead to drugs that could inhibit this metastasis in patients with tumors. ... more

New research from a world-renowned itch expert shows that how good scratching an itch feels is related to the itch ��s location. ... more

Bedwetting isn ��t always due to problems with the bladder. Constipation is often the culprit; and if it isn ��t diagnosed, children and their parents must endure an unnecessarily long, costly and difficult quest to cure nighttime wetting. ... more

Researchers have identified a genetic variation that raises the risk of developing serious necrotic jaw bone lesions in patients who take bisphosphonates, a common class of osteoclastic inhibitors. ... more

Biologists have made an important advance in our understanding of the way cholera attacks the body. The discovery could help scientists target treatments for the globally significant intestinal disease which kills more than 100,000 people every year. ... more

Damaged human heart muscle cannot be regenerated. Scar tissue grows in place of the damaged muscle cells. Scientists are seeking to restore complete cardiac function with the help of artificial cardiac tissue. They have succeeded in loading cardiac muscle cells onto a three-dimensional scaffold, created using the silk produced by a tropical silkworm. ... more

New research could lead to the design of more effective drugs to combat malaria. The research will enable scientists to learn more about the nature of the enzymes required for vitamin biosynthesis by the malaria causing pathogen Plasmodium. Vitamins are essential nutrients required in small amounts, the lack of which leads to deficiencies. Many pathogenic microorganisms produce vitamins, and these biosynthetic pathways may provide suitable targets for development of new drugs. ... more

Scientists have developed a new vaccine to treat cancer at the pre-clinical level. They developed a new approach for treating the disease based on manipulating the immune response to malignant tumors. ... more

In both cell lines and mouse models, grape seed extract kills head and neck squamous cell carcinoma cells, while leaving healthy cells unharmed, new research shows. ... more

Researchers discovered that a prion-like protein plays a key role in storing long-term memories. ... more

Influenza virus can rapidly evolve from one form to another, complicating the effectiveness of vaccines and anti-viral drugs used to treat it. By first understanding the complex host cell pathways that the flu uses for replication, researchers are finding new strategies for therapies and vaccines, according to a new study. ... more

Whenever we fall ill, there are many different factors that come together to influence the course of our illness. Additional medical conditions, stress levels, and social support all have an impact on our health and well-being, especially when we are ill. But a new report suggests that what you think about your illness matters just as much, if not more, in determining your health outcomes. ... more

Nearly two years after the FDA issued what was the first of two rejections, the agency has finally approved the Bydureon diabetes treatment, setting up what is going to be heated battle between Amylin Pharmaceuticals, which will market the drug, and Novo Nordisk, which sells a rival medicine called Victoza. Both drugs are part of the GLP-1 class of diabetes medications (read the FDA letter). The approval was largely expected, given that Amylin had labored to appease the agency, which asked the d ... more

WASHINGTON �� The New England Journal of Medicine on Thursday published an opinion online that called for more rulemaking to govern dietary supplements in an effort to reign in the criminal activity of illicit prescription drug manufacturers that openly disregard the laws currently in effect. Author Pieter Cohen, author of the opinion and an assistant professor of medicine at Harvard Medical School, in his opening paragraph pointed to the recent recall of the product Zotrex. Marketed as a die ... more

WASHINGTON �� The New England Journal of Medicine on Thursday published an opinion online that called for more rulemaking to govern dietary supplements in an effort to reign in the criminal activity of illicit prescription drug manufacturers that openly disregard the laws currently in effect. Author Pieter Cohen, author of the opinion and an assistant professor of medicine at Harvard Medical School, in his opening paragraph pointed to the recent recall of the product Zotrex. Marketed as a die ... more

Large waist circumference and a specific genetic variation may be accurate predictors of an increased risk for metabolic syndrome in children prescribed second-generation antipsychotics. Medscape Medical News ... more

The assay outperformed clinical criteria in identifying patients with early-stage nonsmall-cell lung cancer who were at high risk and who could benefit from additional treatment. Medscape Medical News ... more

Anticipated data include findings from the SWIFT, SPS3, TREVO and WARCEF trials, and more from SAMMPRIS. Medscape Medical News ... more

The FDA has approved axitinib for patients with advanced disease that has progressed after receiving first-line therapy. FDA Approvals ... more

There is a time for sitting in classrooms. When such heady topics as congestive heart failure are abstract and intangible. Discussion veers from myocytes to cardiac output and stroke volume.The world, through the student #8217;s eyes, is inflamed with passion and opportunity. The reality of doctoring is a distant dream. Hope peals back layers of fear and loss of confidence. Reward is imagined as a handshake, a return to health, and gentle guidance and counseling.And there is no better place to b ... more

Study finds high consumption associated with early signs of diabetes, other health issues ... more

Symptom-free patients have no greater risk for gastro infections than general public, study finds ... more

Inlyta is for people who don't respond to another drug ... more

A once-weekly injection ... more

According to Johns Hopkins researchers, individuals who donate a portion of their liver for live transplantation usually recover safely from the procedure and can expect to live long, healthy lives. The study is published in the February issue of the journal Gastroenterology. Dorry L. Segev, M.D., Ph.D., lead author of the study, a transplant surgeon, and an associate professor of surgery and epidemiology at the Johns Hopkins University School of Medicine explains: "The donor process is safer ... more

HIV-positive mothers can protected their babies from becoming infected with the virus if they take antiretroviral drugs during pregnancy. However, even though these drugs prevent transmitting the disease to the child, they could potentially cause birth defects like cleft lip and palate. A new study, published in the January edition of Cleft Palate- "Craniofacial Journal, has investigated the association between antiretroviral prophylaxis and cleft lip and palate... ... more

In the U.S., Keppra® has been approved as adjunctive therapy for partial onset seizures in adults and children aged four years and older with epilepsy. However the UCB recently announced that the U.S. Food and Drug Administration (FDA) has now approved to lower the age restriction to include infants from the age of one month and older with epilepsy. Professor Dr. Iris Loew-Friedrich, Chief Medical Officer and Executive Vice President UCB â�¨declared: â�¨"As a leader in epilepsy UCB has ... more

An international study of asthma, published in the early online version of the European Respiratory Journal, has for the first time, included the number of incidents caused by air pollution and shows that the costs for childhood asthma have risen sharply... ... more

A new study from Henry Ford Hospital in Detroit, presented at the annual Triological Society's Combined Sections Meeting, on January 26 in Miami Beach, shows that diabetes is likely to cause a greater degree of hearing loss in women as they get older, particularly if the diabetes is not well controlled with medication. The study showed that women aged between 60 and 75 years, whose diabetes was controlled appropriately, were able to hear better with similar hearing levels to non-diabetic women o ... more

Not only are relatively few Americans screened for cancer, but there are considerable disparities between ethnic and racial groups in the country, says a new report issued by NCI (National Cancer Institute) and the CDCF (Centers for Disease Control and Prevention). The authors added that screening rates are especially low among Hispanic and Asian Americans. The report is called "Cancer Screening in the United States - 2010." The Healthy People 2020 target of 81% screening rate for breast cancer ... more

According to a study from radiation oncologists at the Kimmel Cancer Center at Jefferson, high-risk prostate cancer patients who receive brachytherapy, alone or together with external beam radiation therapy (EBRT) had considerably lower mortality rates. The study is published online January 23 in the International Journal of Radiation Oncology*Biology*Physics. Brachytherapy is a form of radiotherapy where a radiation source is placed directly at the site of a tumor. The treatment is generally us ... more

Approximately 1 in every 15,000 pregnant women will develop subarachnoid hemorrhage (SAH) - bleeding in the area between the brain and the thin membranes that cover the brain, according to a study published in the February issue of Anesthesiology. The researchers found that: the most common risk factor for pregnancy-related SAH is high-blood pressure disorders its incidence is elevated in pregnant women ruptured aneurysms play a less important role in pregnant patients than non-pregnant patient ... more

Scientists at The University of Texas MD Anderson Cancer Center have identified a self-perpetuating "loop" of molecular activity that fuels pancreatic cancer by linking two signature characteristics of the disease - Kras, a gene that serves as a molecular on-off switch, but gets stuck on the "on" position when mutated, and NF-κB, a protein complex that controls activation of genes. In addition, the team identified a new potential drug target to block this process... ... more

Researchers at the Temple University's School of Medicine recently identified a protein in the brain that could have a major role in regulating the creation of amyloid beta, the major component of plaques implicated in the development of Alzheimer's disease. Three years ago, the presence of the protein, called 12/15-Lipoxygenase, was detected in the brain by leading researcher Domenico Pratico, professor of pharmacology and microbiology and immunology at Temple, who said: "We found this protein ... more

An assay which measures the activity of 14 genes in lung cancer tumors can accurately predict who will respond well to surgery and who will probably die within five years, researchers from the University of California, San Francisco, reported in The Lancet. 80% of lung cancer patients have NSCLC (non-small-cell lung cancer) - their long term prognosis is poor, even after surgical interventions at stages I and II of the disease (early stages), the authors wrote. An assay is an analysis that is ca ... more

A three-dimensional study of how enzymes in the malaria parasite Plasmodium synthesize essential vitamins, could help develop new drugs to combat the disease. Using electron microscopy, a team of scientists from Germany and the UK studied how the enzymes synthesize Vitamin B6, which has already been proposed as a target for new drugs. Dr Ivo Tews, a Lecturer in Structural Biology at the University of Southampton, and colleagues, write about their findings in a paper published online in the jou ... more

A recent study that took place at the Centre for Brain and Cognitive Development, Birkbeck, University of London, and was published in the January edition of Current Biology, states that detecting autism symptoms in babies as young as 6 months old can help to determine how the autism will develop later in the child's life. The researches found that babies show signs of autism in their first year of life. When the babies are looked at, or when someone looks away from them, their brain responds di ... more

The US FDA has approved Inlyta (axitinib) for the treatment of advanced renal cell carcinoma, a type of kidney cancer, in patients with whom other drugs have not been effective, the FDA (Food and Drug Administration) announced today. Inlyta is made and marketed by pharmaceutical giant Pfizer Inc. Renal cell carcinoma - also known as renal cell cancer or hypernephroma, is a type of kidney cancer that starts in the lining of the tiny renal tubes (proximal convoluted tubule). These tubes filter the ... more

A new study from Henry Ford Hospital in Detroit, presented at the annual Triological Society's Combined Sections Meeting, on January 26 in Miami Beach, shows that diabetes is likely to cause a greater degree of hearing loss in women as they get older, particularly if the diabetes is not well controlled with medication... ... more

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Not only are relatively few Americans screened for cancer, but there are considerable disparities between ethnic and racial groups in the country, says a new report issued by NCI (National Cancer Institute) and the CDCF (Centers for Disease Control and Prevention). The authors added that screening rates are especially low among Hispanic and Asian Americans... ... more

The US FDA has approved Inlyta (axitinib) for the treatment of advanced renal cell carcinoma, a type of kidney cancer, in patients with whom other drugs have not been effective, the FDA (Food and Drug Administration) announced today. Inlyta is made and marketed by pharmaceutical giant Pfizer Inc... ... more

Nearly 12,000 people will die of head and neck cancer in the United States this year and worldwide cases will exceed half a million. A study published this week in the journal Carcinogenesis shows that in both cell lines and mouse models, grape seed extract (GSE) kills head and neck squamous cell carcinoma cells, while leaving healthy cells unharmed. #8220;It #8217;s a rather dramatic effect, #8221; says Rajesh Agarwal, PhD, investigator at the University of Colorado Cancer Center and professo ... more

Researchers at the Columbia University College of Dental Medicine have identified a genetic variation that raises the risk of developing serious necrotic jaw bone lesions in patients who take bisphosphonates, a common class of osteoclastic inhibitors. The discovery paves the way for a genetic screening test to determine who can safely take these drugs. The study appears in the online version of the journal The Oncologist. Oral bisphosphonates are currently taken by some 3 million women in the U ... more

Scientists in Trinity College Dublin, Ireland, have developed a new vaccine to treat cancer at the pre-clinical level. The research team led by Professor Kingston Mills, Professor of Experimental Immunology at Trinity College Dublin discovered a new approach for treating the disease based on manipulating the immune response to malignant tumours. The discovery has been patented and there are plans to develop the vaccine for clinical use for cancer patients. The first cancer vaccine Sipuleucel-T ... more

Isolated splenic metastasis from lung cancer is a very rare occurrence with only a few reports available. Here, we report the case of a 82-year-old male who underwent a bilobectomy for a lung squamous cell carcinoma and 16 months later developed an isolated splenic metastasis. Additionally, previous reports are reviewed and discussed. ... more

Background: Lung cancer is a common cause of cancer-related death. Staging typically includes positron emission tomography (PET) scanning, in which 18F-fluoro-2-dexoy-D-glucose (FDG) is taken up by cells proportional to metabolic activity, thus aiding in differentiating benign and malignant pulmonary nodules. Uptake of FDG can also occur in the abdomen. The clinical significance of incidental intraabdominal FDG uptake in the setting of pulmonary nodules is not well established. Our objective was ... more

January is Thyroid Awareness Month. To learn more, visit the thyroid diseases health topic page on MedlinePlus. Also, check out the latest news on thyroid diseases and view the interactive tutorial on thyroid surgery. ... more

Listen to the NLM Director's Comments on "What's the Ultimate Goal of Prostate Cancer Screening?". The transcript is also available. Is the goal of prostate cancer screening to increase its detection, or reduce mortality? This question is posed prominently in a comprehensive study of adult men recently published in the Journal of the National Cancer Institute. ... more

Concerned about your kid ��s weight? Here ��s how to keep your perspective while encouraging better health and self-esteem for your child. ... more

Get tips on how to work with your kid ��s doctor to help your overweight child and deal with childhood obesity. ... more

Dieting isn ��t the answer when it comes to weight loss for kids. Learn to avoid crash diets and unhealthy habits when your doctor suggests safe weight loss. ... more

Pain management is a high priority for patients with rheumatoid arthritis, but a new study shows that minimal or no benefits with muscle relaxants and neuromodulators are outweighted by the risks. ... more

The first Australian patient with leukaemia has been treated with a new investigational anti-cancer drug designed to target cancerous, but not healthy cells. ... more

Benign familial infantile epilepsy (BFIE) has been recognised for some time as infantile seizures, without fever, that run in families but the cause has so far eluded researchers. However clinical res ... more

Researchers have developed what they believe to be the first clinical application of a new imaging technique to diagnose brain tumors. ... more

Roche, a leader in research-focused healthcare with combined strengths in pharmaceuticals, life science tools and diagnostics, announced today that it has commenced a cash tender offer to acquire all outstanding shares of Illumina, Inc. (NASDAQ: ILMN). The offer and withdrawal rights are scheduled to expire at 12:00 midnight, New York City time, at the end of the day on February 24, 2012, unless the offer is extended. ... more

And so, yet another working week will soon draw to a close. As you know, this gives us permission to daydream about weekend plans. We have a very modest agenda, though. A little exercise, a few naps and catching up on some reading. And you? Anything interesting planned? Perhaps, this is an opportunity to spend a few moments with someone special or tidy up around your lily pad. Or as the Republican primary has reminded us, the time is nearly at hand to ready your taxes. Whatever you do, have a gr ... more

Hired someone new and exciting? Promoted a rising star? Finally solved that hard-to-fill spot? Share the news with us and we ��ll share with it others. That ��s right. Send us your announcements and we ��ll find a home for them. Don ��t be shy. Everyone wants to know who is coming and going, especially with all the layoffs. Despite the downsizing, there is movement. Here are some of the latest changes. Recognize anyone? And here is our regular feature. Send us a photo and we will spotlight a dif ... more

Months after we asked whether James Murdoch should remain on the GlaxoSmithKline board (back story), the embattled scion of the Murdoch media empire has decided not to stand for re-election at the upcoming annual shareholder meeting to be held this May. At least, that is the wording in an official statement released this morning by the drugmaker. His three-year stint as a non-executive director has been under a cloud ever since a scandal erupted over charges that various employees in the Murdoch ... more

Between 2000 and 2009, Pfizer stock did not fare so well. As this chart indicates, the shares began the decade hovering around $45, but then dipped to below $14. And so a group of Pfizer employees have filed a lawsuit against the drugmaker, claiming their retirements plans took a beating because these held a disproportionate amount of Pfizer stock. During that stretch, you may recall, Pfizer paid big bucks to swallow up some of its biggest rivals - Warner-Lambert and Pharmacia - in order to gai ... more